The Keithsburg Division of Port Louisa National Wildlife Refuge is mixture of wetland and bottomland forest including sloughs surrounded by bottomland timber. The refuge was established for the protections of more than 275 species of migrating birds along the Mississippi River Flyway. It is a great place to view migrating bird species and waterfowl. Fishing is popular in sloughs and inlets with bluegill and crappie being most common. It also offers squirrel hunting during season. A boat launch is available just north of Keithsburg, though as of September 2020 it is undergoing repairs.